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Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L. Guo W, et al. Neuron. 2022 Mar 16;110(6):1023-1035.e5. doi: 10.1016/j.neuron.2021.12.023. Epub 2022 Jan 19. Neuron. 2022. PMID: 35051376 Free article.
TRPC3 and TRPC6 channels are calcium-permeable non-selective cation channels that are involved in many physiological processes. ...These calcium sensors are also structurally and functionally conserved in TRPC6. We uncovered that the GOF mutations of …
TRPC3 and TRPC6 channels are calcium-permeable non-selective cation channels that are involved in many physiological pr …
Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology.
Yamaguchi Y, Iribe G, Nishida M, Naruse K. Yamaguchi Y, et al. Prog Biophys Mol Biol. 2017 Nov;130(Pt B):264-272. doi: 10.1016/j.pbiomolbio.2017.06.010. Epub 2017 Jun 20. Prog Biophys Mol Biol. 2017. PMID: 28645743 Review.
In particular, TRP canonical (TRPC) channels are known as receptor-operated, non-selective cation channels. TRPC3 and TRPC6, two members in the TRPC family, are highly expressed in the heart, and participate in the pathogenesis of cardiac hypertrophy and hear …
In particular, TRP canonical (TRPC) channels are known as receptor-operated, non-selective cation channels. TRPC3 and TRPC6 …
TRPC channels: Structure, function, regulation and recent advances in small molecular probes.
Wang H, Cheng X, Tian J, Xiao Y, Tian T, Xu F, Hong X, Zhu MX. Wang H, et al. Pharmacol Ther. 2020 May;209:107497. doi: 10.1016/j.pharmthera.2020.107497. Epub 2020 Jan 28. Pharmacol Ther. 2020. PMID: 32004513 Free PMC article. Review.
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-operated calcium-permeable nonselective cation channels of the TRP superfamily. The seven mammalian TRPC members, which can be further divided into four subgroups (TRPC1, TRPC2, TRPC4/5, …
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-operated calcium-permeable nonselective cation …
Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.
Cole BA, Becker EBE. Cole BA, et al. Cells. 2023 Sep 5;12(18):2215. doi: 10.3390/cells12182215. Cells. 2023. PMID: 37759438 Free PMC article. Review.
Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays an essential role in calcium signalling. ...The molecular and structural mechanisms underlying activation and regulation of TRPC3 are …
Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays …
Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis.
Nishiyama K, Toyama C, Kato Y, Tanaka T, Nishimura A, Nagata R, Mori Y, Nishida M. Nishiyama K, et al. Biol Pharm Bull. 2021;44(3):431-436. doi: 10.1248/bpb.b20-00903. Biol Pharm Bull. 2021. PMID: 33642551 Free article.
Two transient receptor potential canonical (TRPC) subfamily members, TRPC3 and TRPC6 (TRPC3/6), reportedly participate in the development of fibrosis in cardiovascular and renal systems. ...Wild-type (WT) and TRPC3 or TRPC6 gene-deficient (KO) m …
Two transient receptor potential canonical (TRPC) subfamily members, TRPC3 and TRPC6 (TRPC3/6), reportedly participate …
The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.
Sexton JE, Desmonds T, Quick K, Taylor R, Abramowitz J, Forge A, Kros CJ, Birnbaumer L, Wood JN. Sexton JE, et al. Neurosci Lett. 2016 Jan 1;610:36-42. doi: 10.1016/j.neulet.2015.10.052. Epub 2015 Oct 28. Neurosci Lett. 2016. PMID: 26520460 Free PMC article.
We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells w …
We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice hav …
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy.
Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, Kurose H. Onohara N, et al. EMBO J. 2006 Nov 15;25(22):5305-16. doi: 10.1038/sj.emboj.7601417. Epub 2006 Nov 2. EMBO J. 2006. PMID: 17082763 Free PMC article.
Among DAG-activating TRPC channels (TRPC3, TRPC6, and TRPC7), the activities of TRPC3 and TRPC6 channels correlated with Ang II-induced NFAT activation and hypertrophic responses. These data suggest that DAG-induced Ca(2+) signaling pathway through …
Among DAG-activating TRPC channels (TRPC3, TRPC6, and TRPC7), the activities of TRPC3 and TRPC6 channels correla …
Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension.
Álvarez-Miguel I, Cidad P, Pérez-García MT, López-López JR. Álvarez-Miguel I, et al. J Physiol. 2017 Mar 1;595(5):1497-1513. doi: 10.1113/JP273327. Epub 2016 Dec 29. J Physiol. 2017. PMID: 27861908 Free PMC article.
We conclude that the increased TRPC3 channel expression in BPH VSMCs leads to changes in TRPC3/C6 heteromultimeric assembly, with a higher TRPC3 channel contribution favouring depolarization of hypertensive VSMCs. ...Consistently, myography stud …
We conclude that the increased TRPC3 channel expression in BPH VSMCs leads to changes in TRPC3/C6 heteromultimeric asse …
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, Zhang X, Chen L. Tang Q, et al. Cell Res. 2018 Jul;28(7):746-755. doi: 10.1038/s41422-018-0038-2. Epub 2018 Apr 26. Cell Res. 2018. PMID: 29700422 Free PMC article.
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient receptor potential (TRPC) channels. They are activated by diacylglycerol, a lipid second messenger. TRPC6 and TRPC3 are involved …
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient re …
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.
Seo K, Rainer PP, Shalkey Hahn V, Lee DI, Jo SH, Andersen A, Liu T, Xu X, Willette RN, Lepore JJ, Marino JP Jr, Birnbaumer L, Schnackenberg CG, Kass DA. Seo K, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. doi: 10.1073/pnas.1308963111. Epub 2014 Jan 22. Proc Natl Acad Sci U S A. 2014. PMID: 24453217 Free PMC article.
Increasing evidence supports a role for the transient receptor potential canonical channels TRPC3 and TRPC6 in this pathophysiology. Channel expression for both is normally very low but is increased by cardiac disease, and genetic gain- or loss-of-function st …
Increasing evidence supports a role for the transient receptor potential canonical channels TRPC3 and TRPC6 in this pathophysi …
358 results